KAT2B (lysine acetyltransferase 2B) is a histone acetyltransferase and transcriptional coactivator with pleiotropic roles in cellular regulation and disease pathogenesis. As a core component of chr3-remodeling complexes, KAT2B catalyzes histone acetylation to regulate transcription of genes involved in metabolism, proliferation, and stress responses 1. Beyond canonical acetylation, KAT2B functions as a crotonyltransferase and lactyltransferase, mediating post-translational modifications of non-histone substrates including PTBP1 and EGR1 to coordinate metabolic reprogramming with gene expression 23. KAT2B is essential for intestinal homeostasis by regulating mitochondrial function and suppressing interferon signaling 4. In cancer biology, KAT2B participates in epithelial-mesenchymal transition through the NELF-E-SLUG-KAT2B axis in breast cancer and regulates ferroptosis susceptibility via FSP1 acetylation in multiple cancer types 56. KAT2B expression is dysregulated in disease states: upregulated in rheumatoid arthritis, pulmonary arterial hypertension, and colorectal cancer, correlating with disease severity and poor prognosis 7. These findings position KAT2B as a critical epigenetic integrator linking metabolism to chr3 dynamics across physiological and pathological contexts.