KCNK15 encodes a two-pore domain potassium channel subunit that exhibits unique functional properties. Unlike most K2P channels, KCNK15 is non-functional as a homodimer but forms functional heterodimeric complexes with TASK-1 and TASK-3 channels 1. These heteromeric complexes display altered single-channel conductance, modified sensitivity to Gq-coupled receptor inhibition, and unique pharmacological properties compared to TASK homodimers 1. KCNK15 negatively modulates surface expression of TASK channels, suggesting a regulatory role in channel trafficking 1. In cancer contexts, KCNK15 expression is consistently downregulated across multiple tumor types including hepatocellular carcinoma, breast cancer, and pancreatic cancer 234. Reduced KCNK15 expression correlates with better prognosis in hepatocellular carcinoma patients and serves as both a diagnostic and prognostic biomarker 2. The gene is subject to epigenetic silencing through promoter hypermethylation in various cancers 5. Additionally, KCNK15 is regulated by its antisense RNA (KCNK15-AS1), which undergoes m6A methylation modifications and influences pancreatic cancer cell motility and proliferation 46. These findings establish KCNK15 as both a functional ion channel component and a clinically relevant cancer biomarker.