KCNK6 (TWIK-2) encodes a two-pore domain potassium channel that regulates K+ efflux and plays critical roles in inflammation and ion homeostasis 1. The channel demonstrates voltage-dependent gating and is insensitive to extracellular pH changes 2. KCNK6 promotes NLRP3 inflammasome activation through accelerated potassium channel activity, contributing to inflammation-associated carcinogenesis and colitis progression 1. Loss of Kcnk6 prevented spontaneous colitis and reduced AOM/DSS-induced carcinogenesis severity in mouse models 1. In the inner ear, TWIK-2 is expressed predominantly in the stria vascularis, suggesting involvement in potassium ion recycling pathways that maintain endolymph composition 3. The channel also participates in electrogenic transport in human endolymphatic sac epithelium, contributing to inner ear fluid homeostasis 4. KCNK6 stability is regulated by METTL3-mediated m6A modification through YTHDF2-dependent mechanisms 1. The gene has been identified as a potential biomarker in bladder cancer prognosis models and shows upregulation in epilepsy models 56. Clinical significance includes potential therapeutic targeting for inflammatory diseases and cancer treatment.