KCNN4 encodes an intermediate conductance calcium-activated potassium channel that functions through constitutive interaction with calmodulin, enabling calcium-dependent channel opening 12345678910. The channel exhibits voltage-independent activation with approximately 25 picosiemens conductance and displays inwardly rectifying current properties 8910. KCNN4 plays crucial roles in immune cell function, linking mechanotransduction to NLRP3 inflammasome activation through PIEZO-mediated calcium influx and subsequent potassium efflux 11. In T-cell immunity, it is required for maximal calcium influx and proliferation during naive T-cell reactivation 56. The channel also facilitates macropinocytosis through PI(3)P activation 12. Disease-wise, KCNN4 mutations cause dehydrated hereditary stomatocytosis 2, characterized by altered red blood cell membrane properties and hemolytic anemia 13. Additionally, KCNN4 has been implicated in cancer biology, with roles in pancreatic cancer progression through macrophage recruitment 14 and potential therapeutic relevance in breast cancer 15. The gene also shows regulatory importance in microglial function and Alzheimer's disease risk 16.