KIF11 is a plus-end-directed microtubule motor protein essential for establishing bipolar mitotic spindles and chromosome 10 during cell division 12. In non-mitotic cells, KIF11 mediates secretory protein transport from the Golgi complex to the cell surface 3. Beyond mitosis, KIF11 localizes to the photoreceptor cilium transition zone, where UFMylation at lysine 953 stabilizes the protein and maintains photoreceptor cilium integrity and retinal homeostasis 4. KIF11 is critical for spindle bipolarization in human oocytes, with mutations identified in infertile patients with oocyte defects 5. KIF11 dysfunction underlies several diseases. Pathogenic KIF11 mutations cause familial exudative vitreoretinopathy (FEVR), a retinal vascular disease 6, and are associated with microcephaly and developmental disorders. Dysregulation drives cancer progression: KIF11 is significantly upregulated in endometrial cancer, esophageal squamous cell carcinoma, and pancreatic ductal adenocarcinoma, correlating with poor prognosis and enhanced tumor proliferation, migration, and chemoresistance 789. KIF11 inhibitors have entered clinical trials as promising cancer therapeutics 1011, with knockdown inducing G2/M phase arrest and apoptosis in cancer cells.