KIF20B is a plus-end-directed kinesin motor protein that plays essential roles in cell division and oncogenesis. Its primary function involves regulating cytokinesis, where it localizes to the central spindle and midbody to ensure proper cell division completion 1. KIF20B controls the speed of furrow ingression and abscission timing, and regulates late midbody maturation steps including anillin dispersal and ESCRT-III recruitment 1. The protein is stabilized through a USP7-FBXO38 pathway, and its depletion leads to cytokinetic defects 2. KIF20B functions as an oncogene across multiple cancer types, being overexpressed in pancreatic adenocarcinoma 3, lung adenocarcinoma 4, and breast cancer 5. In cancer contexts, high KIF20B expression correlates with poor prognosis and advanced disease stages 45. The protein promotes cancer cell proliferation, inhibits apoptosis, and enhances invasion through regulation of β-catenin and LDHA pathways 3. Clinically, KIF20B serves as an independent risk factor for poor outcomes in lung and breast cancers 45, and anti-KIF20B autoantibodies are associated with high disease activity in systemic lupus erythematosus 6. These findings establish KIF20B as both a critical cell division regulator and promising therapeutic target.