KIF2A (kinesin family member 2A) is a plus end-directed microtubule motor protein with critical roles in brain development and cellular mitosis 1. As a member of the kinesin-13 family, KIF2A functions primarily as a microtubule depolymerizing enzyme, regulating microtubule dynamics during axonal growth and spindle assembly 2. The protein is essential for normal progression through mitosis, chromosome 5 at the metaphase plate, and spindle dynamics 1. In the mature brain, KIF2A is required for neuronal survival and maintains dendritic spine density and maturation 3. Loss of KIF2A function leads to cognitive decline and increased tau phosphorylation through ERK1/2 activation 3. Additionally, KIF2A interacts with Smek1 through its Ran-binding domain, and this interaction is crucial for proper axon outgrowth and mitochondrial trafficking 4. Clinically, KIF2A dysregulation is associated with cortical dysplasia and severe brain malformations 1. The protein is also implicated in various cancers, where high expression correlates with poor prognosis, advanced clinical stage, and metastasis 52. In gastric cancer, KIF2A promotes tumor progression via AKT signaling and is upregulated by transcription factor ETV4 6. In hepatocellular carcinoma, KIF2A enhances malignant progression and angiogenesis through interaction with Notch1 signaling 7.