KRT7 (keratin 7) is a structural protein primarily known as a component of intermediate filaments in epithelial tissues 1. Beyond its canonical cytoskeletal role, KRT7 functions as a critical regulator of cancer cell behavior and immune microenvironment remodeling across multiple malignancies. In colorectal cancer, bacterial infection via Fusobacterium nucleatum upregulates KRT7 expression through NF-κB pathway activation, promoting cell migration and lung metastasis 2. In pancreatic ductal adenocarcinoma, KRT7 overexpression drives liver metastasis without affecting primary tumor proliferation, instead remodeling the extracellular matrix niche by promoting FGF2 secretion, which suppresses cancer-associated fibroblast proliferation and ECM deposition 3. In gastric cancer, the transcription factor FOXA1 activates KRT7 to enhance proliferation, migration, invasion, and chemoresistance to 5-fluorouracil 4. Clinically, elevated KRT7 expression correlates with poor prognostic outcomes across bladder cancer 5 and ovarian cancer, where it associates with paclitaxel resistance and reduced CD8+ T cell infiltration while promoting regulatory T cell accumulation 6. These findings establish KRT7 as both a validated prognostic biomarker and a promising therapeutic target in cancer management.