Based on limited published evidence, KRTAP6-3 is a keratin-associated protein with predicted roles in protein binding and cytosolic localization. In sheep, KRTAP6-3 variants have been associated with wool trait modifications including effects on fiber diameter and fleece characteristics 1. In human pathology, KRTAP6-3 was identified as a somatic mutation target in an atypical teratoid/rhabdoid tumor case, though the mutation was subclonal and unexpressed 2. The precise molecular function of KRTAP6-3 remains poorly characterized in human biology.