LIM2 (lens intrinsic membrane protein 2) is a transmembrane protein located on chromosome 19.4 1 that represents the second most abundant protein in the lens 2. Structurally, LIM2 contains four transmembrane domains 3 and localizes to the thicker 16-17 nm junctions of lens fiber cells, where it contributes to cell junctional organization and acts as a calmodulin receptor. The protein plays a critical role in lens fiber cell structure and intercellular communication 1. LIM2 mutations are a major genetic cause of congenital cataract, with both autosomal dominant and recessive inheritance patterns documented 45. The recurrent R130C substitution represents a mutation hotspot, identified across multiple ethnic populations (UK, Czechia, China, Spain, Japan) with diverse phenotypes including nuclear pulverulent, membranous, lamellar, and sutural/lamellar cataracts 42. A Gly154Glu missense mutation causes severe autosomal recessive congenital cataracts through presumed loss of MP19 protein function 5. Clinically, LIM2 mutations are associated with early-onset visual impairment and represent an important component of genetic heterogeneity in hereditary cataract 6. The expanding mutation spectrum across diverse populations highlights LIM2's essential role in lens development and cataractogenesis.