2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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0PubMed Papers
0Diseases
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0Pathogenic Variants
Based on limited published evidence, LOC124908094 encodes the functional WASH1 protein, a core component of the WASH complex that regulates actin dynamics at endosomes 1. The gene was recently identified in the T2T-CHM13 reference assembly within a subtelomeric region previously absent from GRCh38 12. Unlike the previously annotated WASHC1 gene, LOC124908094 demonstrates abundant proteomics support and cDNA evidence for coding status 2. The WASH complex activates Arp2/3 to initiate branched actin networks essential for developmental processes 1.
1
LOC124908094 is the novel WASH1 gene most likely to produce functional WASH1 protein; WASH complex activates Arp2/3 at endosomes
PMID: 373981042
LOC124908094 coding status supported by proteomics, conservation, and cDNA evidence; produces the functional WASH1 protein
PMID: 38464973⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
No pathogenic variants reported on ClinVar for this gene.
No tissue expression data available for this gene.