LPXN (leupaxin) is a focal adhesion adaptor protein with multifaceted regulatory roles in cell migration, transcription, and metabolism. As a transcriptional coactivator, LPXN interacts with hepatic nuclear factor 4α (HNF4α) to promote hepatic gluconeogenesis 1, while also functioning as a coactivator for androgen receptor and serum response factor. LPXN regulates cell adhesion and migration through its interaction with paxillin and Kindlin-3 in integrin adhesion complexes; disruption of Kindlin-3-LPXN binding paradoxically enhances macrophage motility and phagocytosis 2. In prostate cancer, LPXN associates with Pyk2 and PTP-PEST to form signaling complexes that promote migration via Rho GTPase activation 3. LPXN negatively regulates B-cell antigen receptor signaling through Lyn-mediated phosphorylation at Tyr72, suppressing JNK and p38 MAPK activation 4. Pathologically, LPXN expression is elevated in bladder cancer and promotes proliferation, invasion, and angiogenesis through the PI3K/AKT pathway 5. In hepatocellular and renal cancers, LPXN suppression enhances migration and metastasis 6, while in leukemia, LPXN knockdown suppresses proliferation and enhances chemosensitivity 7. Additionally, LPXN promotes lipid storage by stabilizing CIDEC and preventing its ubiquitin-proteasome degradation 8.