LRATD2 (LRAT domain containing 2), also known as FAM84B, is a protein that plays significant roles in cellular trafficking and cancer biology. The protein contains an LRAT (lecithin:retinal acyltransferase) domain with conserved histidine residues (H23 and H35) that are critical for its oncogenic function, though it lacks the cysteine residue (C113) found in related HRASLS family members 1. LRATD2 functions in vesicular trafficking within the secretory pathway, where it associates with vesicle membranes in a GTP-dependent manner and contains proline-rich domains that regulate anterograde trafficking 2. The protein has been identified as a substrate for N-myristoyltransferases (NMT1/2), which catalyze its N-terminal glycine myristoylation 3. In cancer contexts, LRATD2 is frequently amplified and overexpressed across multiple tumor types, including breast, prostate, and pancreatic cancers 45. The gene promotes tumorigenesis through the Wnt/β-catenin signaling pathway, enhancing cell proliferation, mitochondrial function, and glycolysis while suppressing apoptosis 5. LRATD2 overexpression correlates with poor prognosis and reduced survival in various cancers 14, making it a potential therapeutic target for cancer treatment.