LRRC10 (leucine rich repeat containing 10) is a cardiomyocyte-specific protein that functions as a critical modulator of L-type calcium channels (LTCCs) in the heart 1. The protein's primary function involves enhancing L-type calcium current (ICa,L) amplitude by more than doubling channel activity through alterations in channel gating without affecting surface membrane expression 1. LRRC10 associates directly with the CaV1.2 subunit of L-type calcium channels and causes a hyperpolarizing shift in voltage dependence of activation 2. The protein localizes to the dyad region in cardiomyocytes where it interacts with cytoskeletal components including actin and α-actinin at the Z-disc, with His150 being required for actin interaction 34. LRRC10 has significant clinical relevance, as genetic ablation leads to dilated cardiomyopathy (DCM) in mice and zebrafish 15. Human mutations in LRRC10 are associated with idiopathic DCM, with variants like I195T converting LRRC10 from a calcium current potentiator to suppressor 62. The protein is essential for maintaining cardiac performance under mechanical stress, as LRRC10-deficient mice show severe cardiac dysfunction following pressure overload 3.