Based on limited published evidence, LRRC37A3 encodes a leucine-rich repeat-containing protein with unknown molecular function. The gene has been identified in genetic association studies: polymorphisms were associated with severe retinopathy of prematurity in preterm infants 1, and sequence variations were detected in a patient with growth retardation, intellectual disability, joint contracture, and hepatopathy 2. However, the mechanistic role of LRRC37A3 in these conditions remains unclear, and functional studies are needed to establish its biological contribution.