LRRC3C (leucine-rich repeat containing 3C) is a plasma membrane-localized gene with signaling receptor activity located in the 17q12-q21 chr17 region. Limited direct functional data exists for LRRC3C itself; however, expression analysis reveals its involvement in inflammatory and allergic disease susceptibility. LRRC3C expression is increased in colon tissue from individuals without inflammatory bowel disease (IBD) in association with IBD susceptibility alleles 1, suggesting a role in intestinal homeostasis. The gene clusters with GSDMB, GSDMA, and other immunologically relevant genes in a region associated with multiple allergic and inflammatory conditions 2. At the mechanistic level, LRRC3C appears to function within regulatory networks affecting apoptosis and cell proliferation 1. In cancer biology, LRRC3C is located at a recurrently mutated estrogen receptor binding site in breast cancer, where mutations alter chr17 topology and distal gene expression 3, linking LRRC3C to estrogen-responsive regulatory networks. Clinically, LRRC3C variants are associated with increased susceptibility to allergic diseases and IBD, indicating potential therapeutic relevance in inflammatory conditions. However, the specific molecular mechanisms by which LRRC3C mediates these disease associations require further characterization.