LRRIQ3 (leucine rich repeats and IQ motif containing 3) is a protein-coding gene on chromosome 1 with documented protein binding capacity. While its precise molecular function remains incompletely characterized, LRRIQ3 has been identified as a candidate gene associated with neurodevelopmental phenotypes and complex behavioral traits. In a large exome sequencing study of 152 consanguineous families with neurodevelopmental disorders, a homozygous truncating variant in LRRIQ3 was identified as a convincing recessive candidate for intellectual disability, suggesting a potential role in neurodevelopmental processes 1. Additionally, LRRIQ3 has been implicated in opioid-related phenotypes; a genetic variant (rs640561) near LRRIQ3 achieved genome-wide significance in association with problematic opioid prescription use in a GWAS of 132,113 individuals 2, and this same variant showed nominal association with persistent opioid use after surgery 3. LRRIQ3 has also been identified in studies of chr1 pain and major depressive disorder as a gene in a gene-dense chr1 region associated with these conditions 4. Furthermore, LRRIQ3 expression levels have been associated with response to chemoradiotherapy in rectal cancer 5. These findings suggest LRRIQ3 may participate in neurodevelopmental and behavioral processes, though confirmation in independent families is warranted.