2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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8PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
cytoplasmprostate carcinomaUterine leiomyomarenal cell carcinomamultiple sclerosis
Based on limited published evidence, LRRIQ4 is a cytoplasmic protein belonging to a leucine-rich repeat protein family. LRRIQ4 shares evolutionary origin with pannexin and leucine-rich repeat domain proteins 1. Recent genetic studies identified LRRIQ4 polymorphisms within the TERC gene cluster as variants co-varying with absolute telomere length in mice, suggesting potential involvement in telomere length regulation through mechanisms independent of linkage disequilibrium 2. The specific molecular function and cellular role of LRRIQ4 remain largely unknown.
1
LRRIQ4 gene variants in the TERC cluster are associated with telomere length changes in mice, independent of TERC linkage
PMID: 346856032
LRRIQ4 is related to leucine-rich repeat protein families sharing evolutionary origin with pannexin domains
PMID: 22532330⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
prostate carcinomaOpen Targets
Uterine leiomyomaOpen Targets
renal cell carcinomaOpen Targets
multiple sclerosisOpen Targets
lymphoid neoplasmOpen Targets
idiopathic pulmonary fibrosisOpen Targets
postinflammatory pulmonary fibrosisOpen Targets
respiratory system diseaseOpen Targets
uterine fibroidOpen Targets
Barrett's esophagusOpen Targets
melanocytic nevusOpen Targets
myeloproliferative disorderOpen Targets
chronic lymphocytic leukemiaOpen Targets
interstitial lung diseaseOpen Targets
multiple myelomaOpen Targets
Epidermal Inclusion CystOpen Targets
systemic lupus erythematosusOpen Targets
alcohol drinkingOpen Targets
No pathogenic variants reported on ClinVar for this gene.