LUZP2 (leucine zipper protein 2) is a leucine zipper-containing transcription factor predominantly expressed in the nervous system and liver endothelial cells. The gene is located on human chromosome 11-11p14 1. LUZP2 functions as a cell-type-specific transcription factor, with recent evidence identifying it as a novel adult liver sinusoidal endothelial cell-specific transcription factor involved in hepatic development and function 2. In cancer biology, LUZP2 demonstrates significant clinical relevance across multiple malignancies. Pan-cancer analysis reveals that downregulation of LUZP2 correlates with poor overall and progression-free survival in lower-grade glioma (LGG), lung squamous cell carcinoma (LUSC), kidney renal clear cell carcinoma (KIRC), and prostate adenocarcinoma (PRAD) 3. In LGG specifically, LUZP2 downregulation is independently associated with poor outcomes and may be regulated by miR-142-5p, with coexpressed genes involved in nervous system development and metabolic pathways 4. In enzalutamide-resistant prostate cancer, LUZP2 silencing inhibits growth of resistant cells, suggesting therapeutic potential 5. While LUZP2 is expressed in inner ear hair cells and supporting cells, its deletion does not cause hearing loss in mice 6, indicating functional redundancy in auditory systems. Gene targeting disruption does not produce obvious abnormal phenotypes 1.