MAGEE1 (MAGE family member E1) is an X-linked gene encoding a protein that may enhance ubiquitin ligase activity of RING-type E3 ubiquitin-protein ligases through recruitment and stabilization of E2 conjugating enzymes [UniProt]. The protein localizes to multiple cellular compartments including the nucleus, dendrites, plasma membrane, and postsynaptic membrane, suggesting roles in both nuclear and synaptic functions [GO Annotations]. MAGEE1 is uniquely expressed in brain and ovary among normal tissues 1, with specific enrichment in glioblastoma 1. Disease relevance spans multiple pathologies: MAGEE1 was identified within a deletion segregating with autism spectrum disorder in a multiplex family 2, and a rare variant (p.Gly327Glu) was discovered in association with aldosterone-producing adenomas 3. In ovarian clear cell carcinoma, MAGEE1 mutations occur in 19-64% of cases and correlate with worse clinical outcomes; functional studies show that specific MAGEE1 mutants decrease cancer cell proliferation 4. Additionally, MAGEE1 mutations were detected in 37% of melanoma patient samples 5, and the gene was identified as a target of miR-146b-5p with potential roles in inflammatory signaling modulation 6.