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10 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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MALL
mal, T cell differentiation protein like
Chromosome 2 · 2q13
NCBI Gene: 7851Ensembl: ENSG00000144063.5HGNC: HGNC:6818UniProt: Q13021
24PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
membrane raftplasma membraneclathrin-coated vesiclecytoplasmic vesicleneurodegenerative diseasenephronophthisis 1senior-loken syndrome 3cone dystrophy
✦AI Summary

Insufficient information available. The provided PubMed abstracts do not contain research specifically investigating MALL (mal, T cell differentiation protein like) gene function, mechanisms, or disease relevance. The abstracts address unrelated topics including cystic fibrosis pathology 1, caffeine-induced diuresis 2, mall walking programs for exercise 3, synthetic lethality in cancer 4, adult neurogenesis 5, culture-gene coevolution 6, protein sources for nutrition 7, and social norm influences on prosocial behavior 8. While NCBI annotations suggest MALL localizes to cellular membranes and membrane rafts with potential roles in myelin structure and cholesterol homeostasis, no primary literature is provided to support mechanistic details, disease associations, or clinical significance. To generate a comprehensive gene summary, abstracts from studies directly investigating MALL expression, regulation, protein interactions, and biological functions are required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
neurodegenerative diseaseOpen Targets
0.46Moderate
nephronophthisis 1Open Targets
0.33Weak
senior-loken syndrome 3Open Targets
0.33Weak
cone dystrophyOpen Targets
0.26Weak
neoplasmOpen Targets
0.08Suggestive
colorectal cancerOpen Targets
0.03Suggestive
esophageal squamous cell carcinomaOpen Targets
0.03Suggestive
bilirubin metabolism diseaseOpen Targets
0.03Suggestive
cancerOpen Targets
0.03Suggestive
rectum cancerOpen Targets
0.02Suggestive
ulnar-mammary syndromeOpen Targets
0.02Suggestive
squamous cell carcinomaOpen Targets
0.02Suggestive
cervical squamous cell carcinomaOpen Targets
0.01Suggestive
Neoplasm of the lungOpen Targets
0.01Suggestive
adenomaOpen Targets
0.01Suggestive
autism spectrum disorderOpen Targets
0.01Suggestive
Intellectual disabilityOpen Targets
0.01Suggestive
kidney cancerOpen Targets
0.01Suggestive
liver diseaseOpen Targets
0.01Suggestive
NephropathyOpen Targets
0.01Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
NPHP1Protein interaction95%TPD52L2Protein interaction81%CAV1Protein interaction70%CMTM8Shared pathway50%MAL2Shared pathway50%HSDL2Shared pathway50%
Tissue Expression6 tissues
Lung
100%
Liver
11%
Brain
7%
Ovary
5%
Heart
4%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
MALLNPHP1TPD52L2CAV1CMTM8MAL2HSDL2
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q13021
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.91LoF Tolerant
pLIⓘ
0.56Intermediate
Observed/Expected LoF0.29 [0.12–0.91]
RankingsWhere MALL stands among ~20K protein-coding genes
  • #13,235of 20,598
    Most Researched24
  • #8,249of 17,882
    Most Constrained (LOEUF)0.91
Genes detectedMALL
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Cystic fibrosis.
PMID: 39117676
Nat Rev Dis Primers · 2024
1.00
2
[Mechanisms of caffeine-induced diuresis].
PMID: 27225921
Med Sci (Paris) · 2016
0.90
3
Mall Walking Program Environments, Features, and Participants: A Scoping Review.
PMID: 26270743
Prev Chronic Dis · 2015
0.80
4
Synthetic lethality and cancer.
PMID: 28649135
Nat Rev Genet · 2017
0.70
5
Recalibrating the Relevance of Adult Neurogenesis.
PMID: 30686490
Trends Neurosci · 2019
0.60