MANEA — mannosidase endo-alpha

10 sources retrieved · Most recent: April 2026 · Index updated 17 days ago

40PubMed Papers

#10,227 · top 53% of 19K genes

20Diseases

top 58%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

glycoprotein endo-alpha-1,2-mannosidase activityGolgi membraneGolgi apparatusalpha-mannosidase activitypreeclampsiaAbruptio PlacentaeSplenomegalyplacenta praevia

AI Summary

Insufficient information available in the provided abstracts to describe MANEA gene function. While one study reports an association between MANEA variants and anxiety disorders 1, the molecular function and biochemical mechanisms of this α-endomannosidase are not described in the available literature.

Sources cited

Association between MANEA genetic variants and panic disorder/social anxiety disorder

PMID: 24473444

⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.

Disease Associations20

preeclampsiaOpen Targets

0.32Weak

Abruptio PlacentaeOpen Targets

0.29Weak

SplenomegalyOpen Targets

0.25Weak

placenta praeviaOpen Targets

0.25Weak

disease of peritoneumOpen Targets

0.25Weak

Abnormality of the gastrointestinal tractOpen Targets

0.25Weak

chronic venous hypertensionOpen Targets

0.20Weak

complex regional pain syndromeOpen Targets

0.19Weak

obesityOpen Targets

0.17Weak

joint diseaseOpen Targets

0.13Weak

insomniaOpen Targets

0.12Weak

dyshidrosisOpen Targets

0.11Weak

schizophreniaOpen Targets

0.05Suggestive

infectionOpen Targets

0.04Suggestive

neoplasmOpen Targets

0.04Suggestive

intelligenceOpen Targets

0.03Suggestive

premature birthOpen Targets

0.02Suggestive

chondrocalcinosisOpen Targets

0.02Suggestive

crystal arthropathyOpen Targets

0.02Suggestive

lymphomaOpen Targets

0.02Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Related Genes1

MAN1B1Protein interaction94%

Tissue Expression6 tissues

Liver

100%

Heart

81%

Brain

52%

Ovary

42%

Bone Marrow

38%

Lung

36%

Gene Interaction Network1 neighbors

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Structure9 PDB hits

Preparing viewer…

PDB6ZFN · 1.10 Å · X-ray

View on RCSB

ConstraintgnomAD v4.1

LOEUFⓘ

0.93LoF Tolerant

pLIⓘ

0.00Tolerant

Observed/Expected LoF0.63 [0.43–0.93]

Rankings2 dim

Where MANEA stands among ~20K protein-coding genes

#10,201of 20,598
Most Researched40
#8,562of 17,882
Most Constrained (LOEUF)0.93