MEGF10 is a membrane receptor with dual roles in immune clearance and muscle development. As a phagocytic receptor, MEGF10 mediates engulfment of apoptotic cells by macrophages and astrocytes through C1q binding and phosphatidylserine recognition 1. MEGF10 cooperates with ABCA1 in apoptotic cell clearance and promotes formation of intracellular vacuoles for amyloid-beta uptake 23. In the nervous system, MEGF10-mediated astrocytic phagocytosis is necessary for developing cerebellar neuron clearance and, in pathological contexts, synapse elimination after stroke 14. Notably, Sox9-regulated MEGF10 expression in astrocytes promotes amyloid-beta plaque clearance in Alzheimer's disease models 5. In skeletal muscle, MEGF10 regulates satellite cell proliferation and differentiation balance through Notch signaling control, essential for myogenesis 6. The cytosolic domain of MEGF10 independently triggers phagocytosis when incorporated into chimeric antigen receptors, demonstrating functional sufficiency for engulfment 78. Loss-of-function mutations cause early-onset myopathy with areflexia, respiratory distress, and dysphagia (EMARDD), characterized by progressive muscle weakness, feeding difficulties, and respiratory involvement with variable severity depending on mutation type 910.