MEST (mesoderm specific transcript) is an imprinted gene located on human chromosome 7-34 that is expressed exclusively from the paternal allele 1. The gene plays critical roles in early embryonic development, particularly in mesodermal tissue formation 1. MEST functions as a regulator of cell adhesion and signaling pathways essential for proper neuronal development, enabling neurons to transition from bipolar to multipolar shapes during cortical migration through modulation of N-cadherin-dependent adhesion and Akt/Wnt signaling pathways. In cancer biology, MEST promotes metastasis in esophageal squamous cell carcinoma through interaction with PURA protein, activating the SRCIN1/RASAL1-ERK-snail signaling cascade 2. High MEST expression correlates with poor patient survival and enhanced cancer invasion and metastasis 2. The gene also regulates adipogenic differentiation by negatively modulating canonical Wnt signaling through effects on LRP6 coreceptor glycosylation and membrane localization. MEST's imprinted expression pattern makes it susceptible to epigenetic dysregulation, as demonstrated in type 2 diabetic men where MEST hypomethylation in sperm DNA may contribute to fertility issues 3. As the first identified imprinted gene on chromosome 7, MEST represents a candidate for growth-related disorders including Silver-Russell syndrome 1.