MINAR1 (membrane integral NOTCH2 associated receptor 1) is an intrinsically disordered protein that functions as a negative regulator of cell growth and angiogenesis. The protein contains a single transmembrane domain with ~70% of its amino acid sequence being intrinsically unstructured 1. MINAR1 physically interacts with Notch2, increasing its stability and function 1, and negatively regulates mTOR signaling by stabilizing the mTOR complex component DEPTOR 2. In normal tissues, MINAR1 is widely expressed, particularly in breast epithelial and endothelial cells, where it suppresses angiogenesis and tumor growth 1. Clinically, MINAR1 has emerged as a significant disease-associated gene. Genetic variants in MINAR1 are associated with colorectal cancer survival, with the rs72430409 G allele conferring increased death risk in Chinese CRC patients 3. MINAR1 expression is downregulated in advanced breast cancer compared to normal tissue, and re-expression inhibits tumor growth 1. Beyond cancer, MINAR1 is identified as a conserved host dependency factor required for replication of multiple coronaviruses (SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-229E) 45. Recent neurobiological studies reveal MINAR1 expression in forebrain interneurons, where it regulates seizure susceptibility through Gαs-cAMP signaling in somatostatin-positive neurons 6. Additionally, birth epigenetic methylation of MINAR1 is associated with IgE trajectories and airway disease risk 7.