10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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35PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingmotilin receptor bindingextracellular regionhormone activityrheumatoid arthritisPainceliac diseasetype 1 diabetes mellitus
MLN (motilin) is a gastrointestinal hormone that plays a crucial role in regulating digestive motility. According to UniProt annotations, MLN functions in motilin receptor binding and is localized to the extracellular region, where it plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle. However, the provided PubMed abstracts do not contain direct experimental evidence about MLN/motilin gene function. Instead, the abstracts discuss various unrelated topics including: a micropeptide called myoregulin (also abbreviated as MLN) that regulates muscle performance by inhibiting SERCA and calcium handling in skeletal muscle 1; myeloid/lymphoid neoplasms with tyrosine kinase fusions 2; and various studies using 'MLN' as an abbreviation for anatomical structures like mesenteric lymph nodes 3456. The clinical significance and disease relevance of the motilin gene specifically cannot be determined from the provided abstracts, as they do not contain information about the gastrointestinal hormone motilin or its associated disorders.
1
Describes a micropeptide called myoregulin (MLN) that regulates skeletal muscle calcium handling, not the motilin hormone
PMID: 25640239⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
rheumatoid arthritisOpen Targets
celiac diseaseOpen Targets
type 1 diabetes mellitusOpen Targets
Graves diseaseOpen Targets
coronary atherosclerosisOpen Targets
familial glucocorticoid deficiencyOpen Targets
Shoulder painOpen Targets
gastric carcinomaOpen Targets
coronary artery diseaseOpen Targets
multisite chronic painOpen Targets
ulcerative colitisOpen Targets
diabetes mellitusOpen Targets
gastric cancerOpen Targets
respiratory system diseaseOpen Targets
No pathogenic variants reported on ClinVar for this gene.