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10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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MLN
motilin
Chromosome 6 · 6p21.31
NCBI Gene: 4295Ensembl: ENSG00000096395.12HGNC: HGNC:7141UniProt: P12872
35PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingmotilin receptor bindingextracellular regionhormone activityrheumatoid arthritisPainceliac diseasetype 1 diabetes mellitus
✦AI Summary

MLN (motilin) is a gastrointestinal hormone that plays a crucial role in regulating digestive motility. According to UniProt annotations, MLN functions in motilin receptor binding and is localized to the extracellular region, where it plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle. However, the provided PubMed abstracts do not contain direct experimental evidence about MLN/motilin gene function. Instead, the abstracts discuss various unrelated topics including: a micropeptide called myoregulin (also abbreviated as MLN) that regulates muscle performance by inhibiting SERCA and calcium handling in skeletal muscle 1; myeloid/lymphoid neoplasms with tyrosine kinase fusions 2; and various studies using 'MLN' as an abbreviation for anatomical structures like mesenteric lymph nodes 3456. The clinical significance and disease relevance of the motilin gene specifically cannot be determined from the provided abstracts, as they do not contain information about the gastrointestinal hormone motilin or its associated disorders.

Sources cited
1
Describes a micropeptide called myoregulin (MLN) that regulates skeletal muscle calcium handling, not the motilin hormone
PMID: 25640239
⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsⓘ20
rheumatoid arthritisOpen Targets
0.48Moderate
PainOpen Targets
0.44Moderate
celiac diseaseOpen Targets
0.42Moderate
type 1 diabetes mellitusOpen Targets
0.40Weak
Knee painOpen Targets
0.38Weak
Graves diseaseOpen Targets
0.37Weak
coronary atherosclerosisOpen Targets
0.31Weak
familial glucocorticoid deficiencyOpen Targets
0.31Weak
duodenitisOpen Targets
0.31Weak
gastritisOpen Targets
0.31Weak
Neck painOpen Targets
0.30Weak
Shoulder painOpen Targets
0.30Weak
gastric carcinomaOpen Targets
0.30Weak
coronary artery diseaseOpen Targets
0.30Weak
multisite chronic painOpen Targets
0.29Weak
ulcerative colitisOpen Targets
0.29Weak
diabetes mellitusOpen Targets
0.27Weak
gastric cancerOpen Targets
0.25Weak
respiratory system diseaseOpen Targets
0.24Weak
rhinitisOpen Targets
0.24Weak
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
MLNRProtein interaction100%VIPProtein interaction99%TAC1Protein interaction98%GCGProtein interaction98%GHSRProtein interaction93%BRS3Protein interaction92%
Tissue Expression6 tissues
Brain
100%
Lung
67%
Ovary
67%
Heart
0%
Bone Marrow
0%
Liver
0%
Gene Interaction Network
Click a node to explore
MLNMLNRVIPTAC1GCGGHSRBRS3
PROTEIN STRUCTURE
Preparing viewer…
PDB8IBV · 3.19 Å · EM
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
1.63LoF Tolerant
pLIⓘ
0.02Tolerant
Observed/Expected LoF0.81 [0.42–1.63]
RankingsWhere MLN stands among ~20K protein-coding genes
  • #11,012of 20,598
    Most Researched35
  • #15,790of 17,882
    Most Constrained (LOEUF)1.63
Genes detectedMLN
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
A purified membrane protein from
PMID: 32169907
Gut · 2020
1.00
2
Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3.
PMID: 36252111
Circ Res · 2022
0.90
3
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer.
PMID: 36736322
Immunity · 2023
0.80
4
A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.
PMID: 25640239
Cell · 2015
0.70
5
How I diagnose and treat myeloid/lymphoid neoplasms with tyrosine kinase gene fusions.
PMID: 39046810
Blood · 2025
0.60