MMP10 (matrix metallopeptidase 10) is a zinc-dependent endopeptidase that functions both extracellularly and intracellularly to regulate tissue remodeling and inflammatory processes 1. The protein degrades various extracellular matrix components including fibronectin, gelatins, and collagens, while also activating procollagenase. Beyond its classical extracellular role, MMP10 exhibits significant intracellular functions and serves as a biomarker for multiple inflammatory diseases 1. In ulcerative colitis, MMP10 is upregulated years before clinical diagnosis and represents one of eight signature genes involved in acute inflammatory response and immune cell chemotaxis through IL-17, NF-κB, and TNF signaling pathways 23. The protein plays a pathogenic role in neuroinflammation, where microglial PCGF1 suppresses MMP10 transcription via histone modifications, and loss of this regulation contributes to adolescent depression 4. In cardiovascular disease, endothelial MMP10 secretion promotes vascular graft calcification through smooth muscle cell interaction, with TRIM35 normally inhibiting MMP10 expression via RelB ubiquitination 5. MMP10 also serves as a biomarker for eosinophilic asthma and is utilized in forensic applications for menstrual blood identification 67. In emphysema, MMP10 promotes disease progression by influencing macrophage proteolytic and inflammatory activities rather than directly degrading elastin 8.