2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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10PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
cytoplasmschizophreniainsomniaautosomal recessive non-syndromic intellectual disabilityOral ulcer
Based on limited published evidence, MROH6 is a cytoplasmic protein whose specific molecular function remains largely uncharacterized. MROH6 has been identified as a genetic locus associated with interleukin-18 (IL-18) levels in acute coronary syndrome patients, suggesting a potential role in inflammatory regulation 1. Additionally, differential DNA methylation at the MROH6 locus has been associated with gestational diabetes mellitus across pregnancy trimesters, indicating possible involvement in glucose metabolism and metabolic disorder pathogenesis 2. However, mechanistic details of MROH6 function require further investigation.
1
MROH6 genetic variants associated with IL-18 levels in acute coronary syndrome patients
PMID: 257475842
MROH6 identified as a gene with differential DNA methylation signatures in gestational diabetes mellitus
PMID: 41444904⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
schizophreniaOpen Targets
autosomal recessive non-syndromic intellectual disabilityOpen Targets
frozen shoulderOpen Targets
esophageal squamous cell carcinomaOpen Targets
gestational diabetesOpen Targets
breast cancerOpen Targets
chronic myelogenous leukemiaOpen Targets
lung adenocarcinomaOpen Targets
Colon Sessile Serrated Adenoma/PolypOpen Targets
papillary thyroid carcinomaOpen Targets
cervical cancerOpen Targets
neuroblastomaOpen Targets
colorectal cancerOpen Targets
cardiovascular diseaseOpen Targets
type 2 diabetes mellitusOpen Targets
No pathogenic variants reported on ClinVar for this gene.