MTG1 — mitochondrial ribosome associated GTPase 1

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

42PubMed Papers

#9,944 · top 51% of 19K genes

20Diseases

top 56%

0Drugs

0Pathogenic Variants

Hub GeneExperimental GO EvidenceSwiss-Prot Reviewed

GTPase activityprotein bindingmitochondrial inner membranemitochondrial ribosomeneurodegenerative diseaseFamilial prostate cancerprostate cancerprostate carcinoma

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

mitochondrial ribosome associated GTPase 1

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

neurodegenerative diseaseOpen Targets

0.52Moderate

Familial prostate cancerOpen Targets

0.09Suggestive

prostate cancerOpen Targets

0.09Suggestive

prostate carcinomaOpen Targets

0.09Suggestive

Romano-Ward syndromeOpen Targets

0.08Suggestive

catecholaminergic polymorphic ventricular tachycardiaOpen Targets

0.07Suggestive

Familial progressive cardiac conduction defectOpen Targets

0.07Suggestive

Brugada syndromeOpen Targets

0.07Suggestive

Arrhythmogenic right ventricular dysplasiaOpen Targets

0.07Suggestive

hypertrophic cardiomyopathyOpen Targets

0.07Suggestive

familial atrial fibrillationOpen Targets

0.07Suggestive

Rare familial disorder with hypertrophic cardiomyopathyOpen Targets

0.07Suggestive

Familial short QT syndromeOpen Targets

0.07Suggestive

atrial fibrillationOpen Targets

0.07Suggestive

Idiopathic ventricular fibrillation, not Brugada typeOpen Targets

0.06Suggestive

left ventricular noncompactionOpen Targets

0.06Suggestive

sudden cardiac arrestOpen Targets

0.06Suggestive

dilated cardiomyopathyOpen Targets

0.05Suggestive

Atrial stand stillOpen Targets

0.05Suggestive

ventricular fibrillation, paroxysmal familial, type 1Open Targets

0.05Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Liver

100%

Ovary

29%

Lung

23%

Bone Marrow

16%

Brain

Heart

Gene Interaction Network6 neighbors

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Structure5 PDB hits

Preparing viewer…

PDB7O9M · 2.50 Å · EM

View on RCSB

ConstraintgnomAD v4.1

LOEUFⓘ

1.08LoF Tolerant

pLIⓘ

0.00Tolerant

Observed/Expected LoF0.80 [0.59–1.08]

Rankings2 dim

Where MTG1 stands among ~20K protein-coding genes

#9,910of 20,598
Most Researched42
#11,041of 17,882
Most Constrained (LOEUF)1.08