MTMR14 is a lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate at the D-3 position 1, regulating phosphoinositide-dependent cellular processes. The protein localizes to the cytosol and perinuclear region, where it modulates macroautophagy and inflammation 2. MTMR14 suppresses cardiac hypertrophy by inhibiting the Akt signaling pathway 3, and negatively regulates pro-inflammatory M1 macrophage polarization through PI3K/Akt and NF-κB pathways, thereby mitigating COPD progression 45. The protein also participates in Ca2+ homeostasis, a function relevant to myopathy pathogenesis 1. Clinically, mutations in MTMR14 are associated with centronuclear myopathy type 1, a congenital neuromuscular disorder characterized by centrally positioned nuclei in muscle fibers 6. Additionally, MTMR14 overexpression in liver cancer promotes cell survival and migration via modulation of cadherins and suppression of mitochondrial apoptotic pathways 7. MTMR14 expression is regulated by the ubiquitin-proteasome system via TRIM21-mediated degradation 4. These diverse functions position MTMR14 as a multifunctional regulator with therapeutic potential in neuromuscular, cardiovascular, pulmonary, and oncologic diseases.