MTUS2 (microtubule associated scaffold protein 2) is a microtubule-binding protein that regulates cytoskeletal dynamics and cellular processes. The protein binds directly to microtubules and may collaborate with MAPRE1 to target the microtubule depolymerase KIF2C to microtubule plus-ends, potentially regulating microtubule dynamics at growing distal tips. MTUS2 demonstrates significant disease relevance across multiple conditions. In Alzheimer's disease, whole genome sequencing identified MTUS2 variants strongly associated with late-onset disease (rs73154407, p = 7.6 × 10⁻⁹), with associations particularly pronounced in patients with high beta amyloid levels 1. The gene shows tumor suppressor activity in hepatocellular carcinoma, where it acts downstream of circASH2L/miR-525-3p signaling to inhibit cell growth, migration, and invasion 2. MTUS2 variants also associate with body mass index in admixed Brazilian populations, particularly showing female-specific effects 3, and the gene is upregulated in chr13 endometritis during the secretory phase 4. Additionally, MTUS2 appears in molecular signatures associated with myelodysplastic syndrome transplant outcomes 5 and osteoarthritis diagnosis 6. These findings suggest MTUS2 functions as a multifaceted scaffold protein with roles in neurodegeneration, cancer suppression, and metabolic regulation.