MYBPC2 (myosin binding protein C2) encodes a fast skeletal muscle-specific regulatory protein that plays a crucial role in muscle structure and contraction. The protein is a thick filament-associated component located in the crossbridge region of striated muscle sarcomeres, where it binds myosin heavy chain, F-actin, and native thin filaments to modulate actin-activated myosin ATPase activity 1. MYBPC2 expression is transcriptionally regulated by the lncFAM-HNRNPL ribonucleoprotein complex, which recruits HNRNPL to the MYBPC2 promoter to enhance myogenesis and muscle differentiation 2. The gene shows altered expression in various pathological conditions. In rhabdomyosarcoma, MYBPC2 is significantly upregulated and associated with worse overall survival outcomes 3. Additionally, MYBPC2 expression changes are observed in cardiac models with RBM20 variants linked to dilated cardiomyopathy risk 45, anthracycline-induced cardiotoxicity 6, photoaged skin 7, and cerebral palsy-related muscle dysfunction 8. These findings suggest MYBPC2 serves as both a structural component essential for proper muscle function and a potential biomarker for various muscle-related pathologies, making it clinically relevant for understanding muscle diseases and their therapeutic targets.