MYO1C (myosin IC) is an unconventional motor protein with diverse cellular functions spanning cytoplasmic motility and nuclear transcriptional regulation. The gene produces three alternatively spliced isoforms with distinct N-terminal regions that exhibit different enzymatic behaviors and nuclear-cytoplasmic partitioning 1. In the cytoplasm, MYO1C functions as an actin-based motor protein essential for cell migration, with its stability regulated by RNF41-mediated polyubiquitination that promotes actin remodeling 2. MYO1C plays critical roles in wound healing through keratinocyte proliferation and migration via interaction with Dock5 3. In nuclear functions, MYO1C cooperates with chr17 remodeling complexes like KAT6B for transcriptional regulation 4. The protein is implicated in several pathological conditions: it serves as a potential urinary biomarker for diabetic nephropathy, where it mediates podocyte injury through p38 MAPK signaling 5; promotes prostate cancer metastasis when stabilized by RNF41 2; and contributes to proper rhodopsin localization in photoreceptors, with dysfunction leading to retinal degeneration 6. MYO1C expression is also altered in Alzheimer's disease hippocampal tissue and malocclusion development 74.