MZT2A (mitotic spindle organizing protein 2A) is a centrosomal protein essential for microtubule nucleation and spindle formation. Its primary function is recruiting and assembling the gamma-tubulin ring complex (gTuRC) at the centrosome 1. The gTuRC nucleates microtubule polymerization by regulating minus-end nucleation of alpha-beta tubulin heterodimers 2, critical for centrosome duplication and proper spindle organization 3. Specifically, GCP8/MOZART2 (MZT2A) depletion impairs gTuRC recruitment and microtubule nucleation at interphase centrosomes without affecting general centrosome structure 3. Beyond its canonical spindle function, MZT2A exhibits oncogenic activity in multiple cancers. In non-small-cell lung cancer, MZT2A promotes cell viability and invasion by activating Akt phosphorylation through upregulation of LGALS3BP via its MOZART2 domain 4. In lung adenocarcinoma, MZT2A promotes cisplatin resistance by protecting NEMO from deubiquitination, thereby activating NF-κB signaling and suppressing apoptosis 5. MZT2A is overexpressed in renal cell carcinoma and associated with poor prognosis, suggesting roles in immune cell infiltration and tumor microenvironment remodeling 6. These findings establish MZT2A as a potential therapeutic target for cancer progression and chemoresistance.