NAA11 (N-alpha-acetyltransferase 11), also known as ARD1B, is a catalytic subunit of the N-terminal acetyltransferase A (NatA) complex that catalyzes N-terminal acetylation of eukaryotic proteins 1. NAA11 displays alpha-acetyltransferase activity and can interact with auxiliary subunits to form functional NatA complexes 2. Unlike the ubiquitously expressed NAA10 paralog, NAA11 expression is highly tissue-specific and restricted to testicular and placental tissues in humans, with expression epigenetically regulated by CpG island methylation at its promoter 1. NAA11 appears functionally redundant with NAA10, potentially compensating during specific developmental processes such as spermatogenesis 2. In cancer biology, NAA11 represents a cancer-essential gene; dependency screening indicates NAT paralogs including NAA11 are among the most essential genes in tumors 3. Loss of heterozygosity in NAA11 (ARD1B) serves as a prognostic predictor of poor overall survival in hepatocellular carcinoma patients 4. Additionally, NAA11 mutations associate with endometrial adenocarcinoma prognosis through mismatch repair pathway regulation 5, and the NAA11/miR-142-3p regulatory axis influences malignant transformation in IDH-mutant astrocytomas 6.