NBR1 (NBR1 autophagy cargo receptor) is a ubiquitin-binding selective autophagy receptor that plays crucial roles in cellular quality control and immune regulation 1. As a selective autophagy receptor, NBR1 binds both ubiquitinated cargo and autophagy machinery simultaneously to facilitate targeted degradation of specific cellular components 1. NBR1 functions alongside other autophagy receptors including p62, OPTN, and NDP52 in various selective autophagy processes 12. Notably, NBR1 mediates immune evasion in pancreatic ductal adenocarcinoma (PDAC) by targeting MHC-I molecules for autophagy-dependent lysosomal degradation, reducing antigen presentation and enabling tumor escape from T cell recognition 3. This mechanism contributes to PDAC's resistance to immune checkpoint blockade therapy, and autophagy inhibition can restore MHC-I surface expression and enhance anti-tumor immune responses 3. NBR1 also participates in mitophagy pathways that regulate immune responses, as mitophagy can restrict inflammatory cytokine secretion and maintain immune system homeostasis 4. The protein's role in aggrephagy involves clearing protein aggregates, though it specifically targets liquid condensates rather than solid aggregates, which are handled by other receptors like CCT2 5. These diverse functions establish NBR1 as a critical mediator linking autophagy to immune regulation and disease pathogenesis.