NCALD (neurocalcin delta) is a 22 kDa brain-enriched neuronal calcium sensor protein that binds three calcium ions and undergoes calcium-myristoyl switch-mediated membrane binding 1. The gene is abundantly expressed in brain, testis, ovary, and small intestine 2. NCALD interacts with multiple cellular components including clathrin, tubulin, and actin, suggesting roles in vesicle transport and cytoskeletal dynamics. Mechanistically, NCALD regulates adult neurogenesis through interaction with MAP3K10, an upstream JNK activator 3. Complete NCALD knockout impairs hippocampal neurogenesis, while 50% reduction is well-tolerated, supporting therapeutic potential 3. NCALD reduction acts as a protective genetic modifier in spinal muscular atrophy (SMA), with NCALD-ASO treatment significantly ameliorating motor neuron dysfunction and neuromuscular junction denervation in preclinical models 4. Clinically, NCALD has emerging disease relevance: high expression predicts poor prognosis in cytogenetic normal acute myeloid leukemia 5, while low expression correlates with reduced platinum chemotherapy sensitivity in ovarian cancer 6. NCALD is downregulated by miR-182-5p in colorectal cancer, promoting Wnt/β-catenin signaling and tumor progression 7. Genome-wide association studies identified NCALD variants showing pleiotropy for language and memory domains in Alzheimer's disease 8.