NCCRP1 (also known as FBXO50) is an intracellular protein that functions as a component of SCF ubiquitin ligase complexes and promotes cell proliferation 1 2. Structurally, NCCRP1 belongs to the lectin-type subfamily of F-box proteins and lacks signal peptides or transmembrane domains, contradicting its original description as a transmembrane receptor 1. The protein demonstrates significant oncogenic properties in triple-negative breast cancer, where it promotes proliferation, migration, and invasion while suppressing apoptosis and endoplasmic reticulum stress 2. However, NCCRP1 exhibits context-dependent tumor suppressor activity in other cancers. In esophageal squamous cell carcinoma and pancreatic cancer, NCCRP1 expression is frequently lost due to promoter hypermethylation, and low expression correlates with poor prognosis and shorter survival 3 4. The protein is normally expressed in human squamous epithelium and acinar cells, and its silencing reduces cell growth 1. NCCRP1 has emerged as a prognostic biomarker across multiple cancer types and shows potential as a therapeutic target, with its expression levels serving as independent prognostic factors in several malignancies 3 5 2.