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GeneE
25 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
NCOR2
nuclear receptor corepressor 2
Chromosome 12 Β· 12q24.31
NCBI Gene: 9612Ensembl: ENSG00000196498.15HGNC: HGNC:7673UniProt: C9J0Q5
369PubMed Papers
20Diseases
0Drugs
1Pathogenic Variants
FUNCTIONAL ROLE
Hub GeneTranscription Factor
RESEARCH IMPACT
Highly StudiedTrending
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
negative regulation of DNA-templated transcriptionnegative regulation of androgen receptor signaling pathwaynegative regulation of miRNA transcriptionchromatinprostate adenocarcinomaAbnormality of the skeletal systemcolorectal adenocarcinomarespiratory system disease
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

nuclear receptor corepressor 2

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
prostate adenocarcinomaOpen Targets
0.44Moderate
Abnormality of the skeletal systemOpen Targets
0.41Moderate
colorectal adenocarcinomaOpen Targets
0.41Moderate
respiratory system diseaseOpen Targets
0.40Weak
gastric carcinomaOpen Targets
0.37Weak
esophageal adenocarcinomaOpen Targets
0.37Weak
cutaneous melanomaOpen Targets
0.37Weak
skin basal cell carcinomaOpen Targets
0.37Weak
bile duct carcinomaOpen Targets
0.37Weak
breast ductal adenocarcinomaOpen Targets
0.37Weak
carcinoma of liver and intrahepatic biliary tractOpen Targets
0.37Weak
cecum adenocarcinomaOpen Targets
0.37Weak
Hepatobiliary NeoplasmOpen Targets
0.37Weak
HER2 Positive Breast CarcinomaOpen Targets
0.37Weak
kidney neoplasmOpen Targets
0.37Weak
lung carcinomaOpen Targets
0.37Weak
lymphoid neoplasmOpen Targets
0.37Weak
skin carcinomaOpen Targets
0.37Weak
thyroid neoplasmOpen Targets
0.37Weak
viral diseaseOpen Targets
0.37Weak
Pathogenic Variants1
NM_006312.6(NCOR2):c.5909C>A (p.Ser1970Tyr)Likely pathogenic
Multiple myeloma
β˜†β˜†β˜†β˜†2019β†’ Residue 1970
View on ClinVar β†—
Related Genes
RUNX1T1Protein interaction100%RXRGProtein interaction100%ZBTB16Protein interaction100%NR0B2Protein interaction100%PHB2Protein interaction100%NCOA6Protein interaction100%
Tissue Expression6 tissues
Ovary
100%
Lung
100%
Brain
44%
Liver
34%
Bone Marrow
33%
Heart
33%
Gene Interaction Network
Click a node to explore
NCOR2RUNX1T1RXRGZBTB16NR0B2PHB2NCOA6
PROTEIN STRUCTURE
Preparing viewer…
PDB8B94 Β· 1.55 Γ… Β· X-ray
View on RCSB β†—
RankingsWhere NCOR2 stands among ~20K protein-coding genes
  • #830of 20,598
    Most Researched369 Β· top 5%
  • #4,647of 5,498
    Most Pathogenic Variants1
Genes detectedNCOR2
Sources retrieved25 papers
Response timeβ€”
πŸ“„ Sources
25β–Ό
1
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate.
PMID: 32619424
Cell Β· 2020
1.00
2
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
PMID: 32550907
Theranostics Β· 2020
0.96
3
Identification of astrocyte regulators by nucleic acid cytometry.
PMID: 36599367
Nature Β· 2023
0.92
4
HNF4A mitigates sepsis-associated lung injury by upregulating NCOR2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype.
PMID: 39979267
Cell Death Dis Β· 2025
0.88
5
Keratin-positive giant cell-rich tumor review.
PMID: 40555034
Semin Diagn Pathol Β· 2025
0.84