1 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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9PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
GO:0005615spermatogenesis3'-UTR-mediated mRNA stabilizationmRNA 3'-UTR bindinglagophthalmosazoospermiapartial chromosome Y deletionspermatogenic failure 63
Based on limited published evidence, NICOL1 is an mRNA-binding protein that stabilizes target mRNAs including SERPINE1, ACTA2, CCN2, and COL4A1, potentially promoting extracellular matrix production. It binds 3'-UTR regions and may prevent SERBP1-mediated degradation. NICOL1 functions as a testis-derived lumicrine factor regulating epididymal differentiation and sperm maturation. Recent single-cell RNA sequencing identifies NICOL1 as a gatekeeper of trophoblast stem cell state during placental development 1.
1
NICOL1 identified as a gatekeeper of trophoblast stem cell state during early placental differentiation and trophoblast lineage specification
PMID: 39747179⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
lagophthalmosOpen Targets
partial chromosome Y deletionOpen Targets
spermatogenic failure 63Open Targets
spermatogenic failure 83Open Targets
rectosigmoid junction neoplasmOpen Targets
congenital bilateral absence of vas deferensOpen Targets
spermatogenic failure 7Open Targets
spermatogenic failure 71Open Targets
spermatogenic failure 3Open Targets
spermatogenic failure 55Open Targets
spermatogenic failure 16Open Targets
spermatogenic failure 21Open Targets
spermatogenic failure 29Open Targets
Abnormality of the skeletal systemOpen Targets
spermatogenic failure 57Open Targets
spermatogenic failure 79Open Targets
spermatogenic failure 50Open Targets
spermatogenic failure 58Open Targets
spermatogenic failure 10Open Targets
No pathogenic variants reported on ClinVar for this gene.