NIPAL3 (NIPA-like domain containing 3) is a ubiquitously expressed, highly conserved protein 1 involved in magnesium ion transport and protein binding functions. The gene encodes a membrane-associated protein with structural similarity to NIPA family members, which are known receptors and transporters 1. At the molecular level, NIPAL3 functions within competing endogenous RNA networks in keloid fibroblasts, where it serves as a target gene regulated by the long noncoding RNA HOXA11-AS through three microRNAs (hsa-miR-19a-3p, hsa-miR-141-3p, and hsa-miR-140-5p) 2. In skeletal muscle, NIPAL3 was identified as a key interacting gene associated with long-term exercise responses in older adults through artificial neural network analysis 3, though RT-qPCR validation did not show significant differential expression following 6 months of resistance training 3. Clinically, NIPAL3 deficiency results in pleiotropic phenotypes in knockout mouse models, including behavioral impairments, decreased natural killer cell numbers, and immune dysregulation 1. Notably, mutant males exhibited increased IgE levels and impaired lung function, suggesting a role in atopic disease pathogenesis 1. Given that the human NPAL3 gene maps to 1p36.12-p35.1, a region previously linked to atopic diseases, NPAL3 may represent a candidate gene for allergic and immunological disorders.