Based on limited published evidence, NOXRED1 is a probable oxidoreductase containing an NADP-dependent oxidoreductase domain with predicted pyrroline-5-carboxylate reductase activity involved in L-proline biosynthesis. A genetic variant (rs8012548) in NOXRED1 was associated with cutaneous melanoma-specific survival, with the G allele showing altered mRNA expression in skin tissues 1. NOXRED1 has also been identified as a glutamine metabolism-associated gene linked to coronary atherosclerosis risk through bioinformatics analysis 2.