2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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16PubMed Papers
18Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingUDP-sugar diphosphatase activitynucleoplasmGDP-mannose hydrolase activitycancersmoking cessationskin diseaseneoplasm
Based on limited published evidence, NUDT22 is a Mg2+-dependent NUDIX hydrolase that cleaves UDP-glucose and UDP-galactose to produce glucose 1-phosphate (or galactose 1-phosphate) and UMP 1. The enzyme features a unique structural fold with a modified NUDIX domain and N-terminal UDP-binding region. Functionally, NUDT22 promotes pyrimidine salvage in cancer cells by maintaining UMP supply, supporting DNA replication and preventing replication stress 2. NUDT22 expression is elevated in cancer tissues and p53-regulated upon metabolic stress or DNA damage, with high expression correlating with poor survival outcomes.
1
Characterization of human NUDT22 as a UDP-glucose/galactose hydrolase with unique structural features including modified NUDIX box and N-terminal UDP-binding domain
PMID: 294133222
NUDT22 promotes cancer growth through pyrimidine salvage, maintains DNA replication fork progression, and is p53-regulated in response to metabolic stress and DNA damage
PMID: 36871087⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
smoking cessationOpen Targets
breast cancerOpen Targets
lung adenocarcinomaOpen Targets
cervical cancerOpen Targets
cholangiocarcinomaOpen Targets
colon adenocarcinomaOpen Targets
colorectal adenocarcinomaOpen Targets
gastric cancerOpen Targets
glioma susceptibility 1Open Targets
uterine corpus endometrial carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.