NUFIP2 (nuclear FMR1 interacting protein 2) is an RNA-binding protein that functions as a cofactor in multiple cellular processes involving RNA metabolism and stress responses. NUFIP2 directly binds to and stabilizes Roquin proteins with high affinity, contributing to post-transcriptional regulation of target mRNAs such as ICOS through cooperative recognition of stem-loop structures in 3'-UTRs 1. The protein is a core component of stress granules (SGs), ribonucleoprotein condensates that form under cellular stress conditions 2. During lysosomal damage, NUFIP2 is recruited to damaged lysosomes independently of canonical autophagy, where it contributes to MTOR inactivation via the Ragulator-RRAGA-RRAGB complex 2. NUFIP2 also interacts with FMRP as part of cellular stress response networks 3. In neurodegenerative diseases, NUFIP2 serves as a context-dependent interactor that can sequester TDP-43 into cytoplasmic aggregates and co-localizes with TDP-43 pathology in ALS/FTLD patient tissues 4. The protein's solubility is regulated by O-GlcNAcylation, which affects its participation in biomolecular condensate formation 5. NUFIP2 dysregulation has been implicated in various pathological conditions including cancer and kidney stone formation 678.