NUGGC is a nuclear GTPase selectively expressed in germinal center B cells where it functions to inhibit activation-induced cytidine deaminase (AICDA) 1. The protein localizes to nuclear replication factories and reduces somatic hypermutation in B cells, thereby enhancing genome stability 1. NUGGC knockdown increases DNA breaks and apoptosis through AID-dependent mechanisms, suggesting it plays a critical protective role during antibody diversification 1. Clinically, NUGGC has emerged as a disease-associated gene across multiple pathologies. Copy number variations (CNVs) encompassing NUGGC are strongly associated with umbilical hernia pathogenesis in pigs and have been implicated in human omphalocele and inguinal hernia 2. NUGGC was identified as a novel susceptibility locus for venous thromboembolism in a large genome-wide association study 3, and differential expression of NUGGC correlates with diet-induced obesity in animal models 4. Additionally, NUGGC fusion with BCOR has been documented in endometrial stromal sarcomas 5. These diverse associations suggest NUGGC dysfunction contributes to multiple disease phenotypes beyond its characterized B-cell immunological function, though the molecular mechanisms in non-B-cell contexts remain unclear.