NVL (nuclear VCP-like) is a multifunctional AAA-ATPase that plays critical roles in telomerase assembly and ribosome biogenesis. The protein participates in telomerase holoenzyme assembly through direct interaction with TERT, which is essential for telomerase activity 1. NVL is involved in both early and late stages of pre-rRNA processing pathways and spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus 1. The protein catalyzes the ATP-dependent release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles during ribosome maturation. NVL's subcellular localization can be modulated by bacterial pathogens, as demonstrated by Brucella effectors that sequester SENP3 and promote cytoplasmic accumulation of NVL along with ribosomal protein L5 2. Disease relevance includes psychiatric disorders, as genetic variants in NVL confer overlapping risk for both major depressive disorder and schizophrenia in Han Chinese populations 1. Additionally, NVL has been identified as an autoantigen in systemic sclerosis patients, suggesting potential autoimmune implications 3. The protein's dual roles in telomerase function and ribosome biogenesis highlight its importance in cellular homeostasis and disease pathogenesis.