NYNRIN (NYN domain and retroviral integrase containing) is an RNA-binding protein with endonuclease activity involved in mRNA regulation and cytoplasmic ribonucleoprotein granule function. The gene encodes a protein containing NYN and retroviral integrase domains, which mediate 3'-UTR-directed mRNA destabilization and mRNA binding activity 1. NYNRIN functions as a metastasis suppressor in melanoma; reduced NYNRIN expression increases invasive activity in human melanoma cells 2. The gene is implicated in multiple cancer predisposition syndromes. Biallelic truncating mutations in NYNRIN occur in approximately 6.6% of bilateral Wilms tumor cases with germline predisposition 3, and its mutations were identified as one of four new Wilms tumor predisposition genes with highly significant statistical enrichment 4. NYNRIN has also emerged as a novel candidate gene for congenital heart disease susceptibility, identified through comprehensive genomic meta-analysis 5. Additionally, NYNRIN was identified as a key biomarker for periodontitis through integrative multiomics analysis, with expression levels correlating with immune cell infiltration patterns 6. These findings collectively suggest NYNRIN's critical roles in developmental processes and cancer suppression, with potential clinical significance for genetic testing and early disease detection.