10 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
17PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
calcium ion bindingprotein bindingcytoplasmtype 1 diabetes mellitusplacenta praeviadeafnesshearing loss, autosomal recessive
Oncomodulin (OCM) is a calcium-binding protein with calmodulin-like activity involved in growth regulation and cell signaling. The protein binds two calcium ions and localizes to the cytoplasm where it exhibits protein-binding capabilities [UniProt]. OCM functions as a myeloid cell-derived growth factor that promotes axon regeneration following nerve injury in mice and rats 1. Mechanistically, OCM exerts its regenerative effects through binding to its high-affinity receptor ArmC10 (armadillo-repeat protein C10), which is expressed in sensory neurons and immune cells 1. ArmC10 deletion suppresses inflammation-induced axon regeneration in optic nerves and impairs the conditioning lesion effect for peripheral and spinal cord axon regeneration 1. Beyond nerve repair, OCM modulates immune function by increasing expression of immunomodulatory genes in human monocytes 1. In human-induced pluripotent stem cell-derived sensory neurons, OCM exposure alters gene expression and enhances neurite outgrowth 1. These findings suggest therapeutic potential for OCM-ArmC10 signaling in treating nerve injuries and modulating immune responses, though clinical translation requires further investigation.
1
Oncomodulin is a myeloid cell-derived growth factor enabling axon regeneration through binding to ArmC10 receptor; ArmC10 deletion suppresses nerve regeneration and OCM enhances neurite outgrowth in human sensory neurons
PMID: 37556559⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
type 1 diabetes mellitusOpen Targets
placenta praeviaOpen Targets
hearing loss, autosomal recessiveOpen Targets
autosomal dominant nonsyndromic hearing lossOpen Targets
Non-syndromic genetic deafnessOpen Targets
X-linked nonsyndromic hearing lossOpen Targets
autosomal dominant nonsyndromic hearing loss 17Open Targets
autosomal dominant nonsyndromic hearing loss 7Open Targets
autosomal recessive nonsyndromic hearing loss 102Open Targets
deafness, aminoglycoside-inducedOpen Targets
Mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposureOpen Targets
autosomal recessive nonsyndromic hearing loss 86Open Targets
hearing loss, autosomal dominant 88Open Targets
hearing loss, autosomal dominant 89Open Targets
auditory neuropathy, autosomal dominant 3Open Targets
autosomal recessive nonsyndromic hearing loss 1BOpen Targets
autosomal dominant nonsyndromic hearing loss 65Open Targets
Meniere diseaseOpen Targets
No pathogenic variants reported on ClinVar for this gene.