2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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22PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
calcium ion bindingcytoplasmprostate carcinomadeafnesshearing loss, autosomal recessiveautosomal dominant nonsyndromic hearing loss
Based on limited published evidence, OCM2 is a calcium-binding protein localized to the cytoplasm. The gene was identified through whole exome sequencing as harboring a rare coding variant (c.227G>C, p.Arg76Thr) in a heterozygous state in an individual with non-syndromic hearing impairment from Cameroon 1. In silico analyses suggest OCM2 may have functional co-expression interactions with established hearing impairment genes GJB2 and GJB6, though the precise molecular function and role in hearing physiology remain unclear.
1
OCM2 variant c.227G>C identified in hearing impairment patient; suggested functional interactions with GJB2/GJB6
PMID: 32996353⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
prostate carcinomaOpen Targets
hearing loss, autosomal recessiveOpen Targets
autosomal dominant nonsyndromic hearing lossOpen Targets
Non-syndromic genetic deafnessOpen Targets
X-linked nonsyndromic hearing lossOpen Targets
autosomal dominant nonsyndromic hearing loss 17Open Targets
autosomal dominant nonsyndromic hearing loss 7Open Targets
autosomal recessive nonsyndromic hearing loss 102Open Targets
deafness, aminoglycoside-inducedOpen Targets
Mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposureOpen Targets
autosomal recessive nonsyndromic hearing loss 86Open Targets
hearing loss, autosomal dominant 88Open Targets
hearing loss, autosomal dominant 89Open Targets
auditory neuropathy, autosomal dominant 3Open Targets
autosomal recessive nonsyndromic hearing loss 1BOpen Targets
autosomal dominant nonsyndromic hearing loss 65Open Targets
Meniere diseaseOpen Targets
autosomal recessive nonsyndromic hearing loss 30Open Targets
hearing loss, X-linked 4Open Targets
No pathogenic variants reported on ClinVar for this gene.
No tissue expression data available for this gene.