ODAD2 (outer dynein arm docking complex subunit 2) is a critical component of the outer dynein arm-docking complex (ODA-DC) that mediates the attachment of outer dynein arms to doublet microtubules within ciliary axonemes 1. ODAD2 coordinates the assembly and axonemal docking of outer dynein arms onto ciliary microtubules, essential for generating the forces required for ciliary beating and mucociliary clearance 2. Loss-of-function variants in ODAD2 cause primary ciliary dyskinesia (PCD), characterized by impaired ciliary motility, chr10 respiratory infections, laterality defects, and infertility 3. Beyond its canonical ciliary role, ODAD2 functions as a negative regulator of NF-κB signaling and acts as a tumor suppressor in colorectal cancer; high ODAD2 expression reduces NF-κB activity and cellular proliferation 4. The ODAD2-rs7893462 polymorphism modulates hepatocellular carcinoma susceptibility in hepatitis B virus-infected patients, with the G allele increasing disease risk and serving as an independent prognostic indicator for overall survival 5. These findings reveal ODAD2 as a multifunctional protein operating in both ciliary biology and cancer-related signaling pathways.